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mTOR inhibitor 10
CAS No. 1222999-54-3
mTOR inhibitor 10( —— )
Catalog No. M10850 CAS No. 1222999-54-3
A novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamemTOR inhibitor 10
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1.
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DescriptionA novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM; displays >50-fold selectivity over PIKKs (hVSP34, PI3Ks, PI4K, etc.); exhibits significant inhibitory activity against the downstream targets of mTOR, S6K, and Akt, and blocks 80-90% phosphorylation of S6K (T389) and pAkt (S473) in liver and lung tissues, along with significantly improved mouse liver microsome stability and a longer in vivo half-life.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptormTOR
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Research Area——
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Indication——
Chemical Information
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CAS Number1222999-54-3
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Formula Weight683.735
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Molecular FormulaC41H32F3N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1CCC(CC1)NC(=O)C2=CC=C(C=C2)C3=C(C=C(C=C3)N4C(=O)C=CC5=CN=C6C=CC(=CC6=C54)C7=CC8=CC=CC=C8N=C7)C(F)(F)F
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Chemical NameN-(1-methylpiperidin-4-yl)-4'-(2-oxo-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-1(2H)-yl)-2'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu Q, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4036-40.
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